AriaNova Bio
King Skin herbal ointment — botanical laboratory showcase with AriaNova Bio branding

Wound-Care Research Program

King Skin

Herbal-Based Therapeutic
for Chronic Wound Healing

King Skin is AriaNova Bio's herbal-based wound-care research program, formulated from natural herbal compounds. It is being studied for its potential to support wound healing, reduce scarring, and help address chronic and complex wounds.

Science & EvidenceAbout AriaNova Bio

The Burden of Complex Wounds

Selected U.S. and global indicators illustrating the burden of chronic wounds, diabetic limb loss, burns, pressure injuries, and venous leg ulcers.

0.0M[1]

Medicare beneficiaries affected by chronic wounds in the United States

$0.0B[2]

Estimated Medicare wound-care expenditure in 2019

0K[3]
/ year

Lower-extremity amputation hospital discharges among U.S. adults with diabetes in 2021

Calculated rate: ≈ one every 3.2 minutes

0.0M[4]
/ year

Diabetes-associated lower-extremity amputation procedures globally

Calculated rate: ≈ one every 21 seconds

0K[5]
/ year

Fire- or burn-related injuries reported in the United States in 2021

0.0M[6]
/ year

Estimated global incident cases of injuries caused by fire, heat, and hot substances in 2021

0.0M+[7]
/ year

People who develop pressure ulcers in the United States each year

0K–
0K[1]

Estimated people affected by venous leg ulcers in the United States

References

  1. [1] Sen CK. Human Wound and Its Burden: Updated 2022 Compendium of Estimates. Advances in Wound Care. 2023;12(12):657–670. doi:10.1089/wound.2023.0150.
  2. [2] Carter MJ, DaVanzo J, Haught R, Nusgart M, Cartwright D, Fife CE. Chronic wound prevalence and the associated cost of treatment in Medicare beneficiaries: changes between 2014 and 2019. Journal of Medical Economics. 2023;26(1):894–901. doi:10.1080/13696998.2023.2232256.
  3. [3] Centers for Disease Control and Prevention. National Diabetes Statistics Report / U.S. Diabetes Surveillance System. Hospitalization data for U.S. adults with diabetes, 2021. Lower-extremity amputation hospital discharges: 166,000.
  4. [4] Humphries MD. Social and Structural Determinants of Lower Extremity Amputations in Diabetes. Current Diabetes Reports. 2025;25(1):40. doi:10.1007/s11892-025-01598-y.
  5. [5] American Burn Association. Burn Incidence and Treatment in the United States. Based on CDC National Hospital Ambulatory Medical Care Survey 2021 data. Reported fire- or burn-related injuries: 398,000.
  6. [6] Shao J, Zhu Y, Xie M, et al. Global burden of fire-, heat-, and hot substance-related injuries, 1990–2021: A systematic analysis for the Global Burden of Disease Study 2021. Medicine. 2026;105(30):e49884. doi:10.1097/MD.0000000000049884.
  7. [7] Agency for Healthcare Research and Quality. Pressure Ulcers. More than 2.5 million people in the United States develop pressure ulcers each year.

Our Approach

King Skin

A Research-Stage Topical Formulation for Wound Care

King Skin is AriaNova Bio's herbal-based topical formulation being investigated for wound-care applications. Historical case observations have motivated further scientific evaluation of its potential benefits.

Program Advantages

Key Advantages of the King Skin Program

Based on historical program experience and product-development observations, King Skin has been associated with several practical wound-care advantages.

25 Key Advantages

Category 01

Wound Healing & Skin Regeneration

10 Advantages
  • Rapid Visible Improvement01
  • Wound Closure & Re-epithelialization02
  • Supports Granulation Tissue03
  • Reduced Visible Scarring04
  • Skin Tone Recovery05
  • Hair Regrowth06
  • Improved Skin Texture07
  • Restores Skin Flexibility08
  • Effective in Complex Wounds09
  • Broad Range of Wound Types10

Category 02

Patient Experience & Practical Care

8 Advantages
  • Reported Pain Relief01
  • Reduced Visible Inflammation02
  • Simple Topical Application03
  • Simplified Wound Care04
  • Debridement Support05
  • Graft-Sparing Potential06
  • Potential to Reduce Need for Advanced Dressings07
  • Facilitates Return to Daily Activities08

Category 03

Formulation & Product Characteristics

5 Advantages
  • Herbal-Based Natural Ingredients01
  • Preservative-Free Formulation02
  • Long Shelf Life03
  • Scalable Manufacturing04
  • Potential Cost-Effectiveness05

Category 04

Biological Properties (Under Evaluation)

2 Advantages
  • Antimicrobial Support01
  • Anti-Inflammatory Support02

These biological properties are currently under scientific evaluation. Results from ongoing in vitro studies will inform future regulatory submissions.

These advantages are based on historical clinical use and product-development observations. They are observational and do not establish clinical efficacy. Controlled studies are needed to further evaluate these potential benefits. Controlled studies are needed to evaluate these potential benefits.

Regulatory Development

FDA Validation Pathway

King Skin is advancing through a structured regulatory development process toward FDA submission.

01

Stage 01

Clinical Use in Iran

Achieved

Many patients have been treated, with real-world outcomes typically occurring within less than a month.

02

Stage 02

In Vitro Validation

In Progress

Six laboratory studies conducted at CIC St. Louis to generate scientific evidence.

03

Stage 03

Regulatory Preparation

Compilation of safety, efficacy, and manufacturing data for FDA pre-submission.

04

Stage 04

FDA Submission

Formal regulatory submission for U.S. market authorization.

Interested in the King Skin Program?

Reach out to the AriaNova Bio team to learn more about our wound-care research, validation data, or partnership opportunities.

Contact UsScience & Evidence